Youth and young adults who experience homelessness or housing instability are at significant risk of poorer physical and mental health outcomes, disrupted education, and long-term economic instability. To better understand these challenges in Mid- and Southeast Michigan, the MSEMI Youth Homelessness Regional Partnership (MSEMI YHRP), led by Lighthouse in collaboration with a steering committee of partnership representatives, conducted a regional youth needs assessment. This report examines youth homelessness and housing instability in ten counties—Genesee, Huron, Lapeer, Livingston, Macomb, Oakland, St. Clair, Sanilac, Shiawassee, and Tuscola—and identifies key factors shaping young people’s experiences with housing and support services.